Nutritional Endocrinology Practitioner Training (NEPT)
November 17th, 2017
One of our IRSPT students asked me to comment on the impact of saturated fats on insulin resistance. There are people who claim it’s not sugar that causes insulin resistance , its fat, especially saturated fat.
I think the answer is a bit more complex than people make it out to be. Oxidized fats, poor quality fates, and too much omega 6 and saturated fats certainly have an impact.
I plan to write more in-depth article about this, and to comment on the articles below .
I’d love your opinion about these
Does Increasing circulating free fatty acids in humans rapidly induces insulin resistance ?
What Causes Insulin Resistance? Part I
Insulin resistance is a cellular antioxidant defense mechanism
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
Effect of fatty acids on glucose production and utilization in man
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.
Interaction between glucose and free fatty acid metabolism in human skeletal muscle.
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC407880/
Dose-response effect of elevated plasma free fatty acid on insulin signaling.
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.