Nutritional Endocrinology Practitioner Training (NEPT)
Clinical Pearl

November 17th, 2017

One of our IRSPT students asked me to comment on the impact of saturated fats on insulin resistance.  There are people who claim it’s not sugar that causes insulin resistance , its fat, especially saturated fat.

I think the answer is a bit more complex than people make it out to be.  Oxidized fats, poor quality fates, and too much omega 6 and saturated fats certainly have an impact.

I plan to write  more in-depth article about this, and to comment on the articles below .

I’d love your opinion about these

Does Increasing circulating free fatty acids in humans rapidly induces insulin resistance ?

What Causes Insulin Resistance? Part I

http://wholehealthsource.blogspot.my/…/what-causes-insulin-…

Insulin resistance is a cellular antioxidant defense mechanism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764908/

Lipid overload and overflow: metabolic trauma and the metabolic syndrome

https://www.ncbi.nlm.nih.gov/pubmed/14580758

Effect of fatty acids on glucose production and utilization in man

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC370462/

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.

https://www.ncbi.nlm.nih.gov/pubmed/1885781

Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC293539/

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC407880/

Dose-response effect of elevated plasma free fatty acid on insulin signaling.

https://www.ncbi.nlm.nih.gov/pubmed/15919784

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

https://www.ncbi.nlm.nih.gov/pubmed/10480616